Snail1 transcription factor controls telomere transcription and integrity

Snail1 transcription factor controls telomere transcription and integrity

Besides controlling epithelial-to-mesenchymal transition (EMT) and cell invasion, the Snail1 transcriptional factor also provides cells with cancer stem cell features. Since telomere maintenance is essential for stemness, we have examined the control of telomere integrity by Snail1. Fluorescence in situ hybridization (FISH) analysis indicates that Snail1-depleted mouse mesenchymal stem cells (M...

Differential expression of Snail1 transcription factor and Snail1-related genes in alveolar and embryonal rhabdomyosarcoma subtypes.

Rhabdomyosarcoma (RMS) represents the most common sarcoma of soft tissue among children. Two main RMS subtypes are alveolar (ARMS) and embryonal (ERMS). The major goal of this study was to find differentially expressed genes between RMS subtypes that could explain higher metastatic potential in ARMS and would be useful for the differential diagnosis. Using RQ-PCR analysis we compared expression...

metabolic syndrome and mitochondrial transcription factor a

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.

Tissue-specific gene expression requires modulation of nucleosomes, allowing transcription factors to occupy cis elements that are accessible only in selected tissues. Master transcription factors control cell-specific genes and define cellular identities, but it is unclear if they possess special abilities to regulate cell-specific chromatin and if such abilities might underlie lineage determi...

Intestinal Master Transcription Factor Cdx2 Controls Chromatin 1 Access for Partner Transcription Factor Binding 2 3

1 Intestinal master transcription factor CDX2 controls chromatin 1 access for partner transcription factor binding 2 3 Michael P. Verzi*, Hyunjin Shin*, Adrianna K. San Roman, 4 X. Shirley Liu, and Ramesh A. Shivdasani 5 6 7 Department of Medical Oncology and Department of Biostatistics and Computational Biology, 8 Dana-Farber Cancer Institute, Boston, MA 02215 (USA); Departments of Medicine, B...